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MRI findings drastically changed during the phases of disease process in one case.In the early phase,T2-weighted MR images demonstrated hyperintensity in both basal ganglia and thalamus.MR images obtained in the late phase demonstrated markedly advanced brain atrophy and diffuse white matter lesions,which were hyperintense on the T2-weighted images.T1- weighted images exhibited hyperintensity in the basal ganglia,thalamus,and along the cortical layer of the cerebrum,which appeared to be hypointense on T2-weighted images.MR was apparently superior to CT in clearly delineating lesions of this disease.These abnormal signal intensities in the late phase may reflect the pathological findings,marked accumulation of GM2 ganglioside in the basal ganglia and thalamus and along the cerebral gray matter. |
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basal ganglia,lesion of
CAT scan
CAT scan,abnormal
gangliosidosis GM2
lenticular nucleus,lesion of,bilateral
MRI
MRI,abnormal
MRI,CAT scan compared to
Tay-Sachs disease
thalamus,lesion of
thalamus,lesion of-bilateral
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